ML-60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.¹   Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.²

References/Citations

1) Wu et al. (2003), Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell, 2 256

2) Yee et al. (2012), Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open, 1(4) 295